Intestinal Absorption of Mercury in Vitro from Intestinal Contents of Methylmercury Administered Mice
نویسندگان
چکیده
Intestinal flora plays an important role in the decomposition and fecal excretion of methylmercury. The assumed mechanism is that decomposition of organic mercury (o-Hg) to inorganic mercury (i-Hg) by intestinal flora in cecum decreases the reabsorption of mercury in large intestines. To confirm this hypothesis, we examined the large intestinal mercury absorption in vitro from intestinal contents of methylmercury administered mice. Methylmercury (2 mg Hg/kg) was administered intraperitoneally to adult female mice, and the contents of small intestine (ileum) and cecum were taken out 24 hr after the administration. Ratios of organic mercury to total mercury in small intestinal content and cecal content were 86% and 49%, respectively.
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and intestinal contents is also apparent from a time-course graph (Fig. 1). The amount of methylmercuric chloride produced by the caecal contents is not directly proportional to the time of incubation, but instead rises rapidly to a peak at 2670h and then falls with further incubation. In the presence of the intestinal contents, the peak (at 48h) is sharper, and virtually no HgCI, is methylated...
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